Scientist, CAR-T Cell Development

Job description

Janssen Research and Development, L.L.C., a member of Johnson and Johnson's Family of Companies, is recruiting for a Scientist, CAR-T Immunobiology located in Spring House, PA.

At the Janssen Pharmaceutical Companies of Johnson & Johnson, what matters most is helping people live full and healthy lives. We focus on treating, curing and preventing some of the most devastating and complex diseases of our time. And we pursue the most promising science, wherever it might be found.

Janssen Biotech, Inc. delivers on the promise of new treatments and ways to improve the health of individuals with serious disease. Built upon a legacy of innovative firsts, Janssen Biotech pursues advancing patient care with immunology and oncology solutions. Please visit www.JanssenBiotech.com for more information.

We are Janssen. Our mission drives us. Our patients inspire us. We collaborate with the world for the health of everyone in it.

Thriving on a diverse company culture, celebrating the uniqueness of our employees and committed to inclusion. Proud to be an equal opportunity employer.

The Scientist will be utilizing highly specialized experience and knowledge, this position will be accountable for designing and executing research and development activities focused on cell engineering using gene-editing technologies with an initial focus on primary human T cells. Key responsibilities include, but are not limited to: Providing functional laboratory-based expertise for implementation of CAR T-based applications; design and execution of strategies to engineer cells for drug discovery and engineered T cell platform development; interacting with research teams focused on biologics drug discovery. The Scientist will:

· Contribute to cell engineering research, assay development and execution, and engineered T cell platform development.
· Functionally characterize and immunophenotype T-cell populations using various flow cytometry techniques (i.e., surface marker expression, intracellular cytokine staining, cytometric bead arrays, etc.).
· Possess a working knowledge of gene-editing technologies including CRISPR, TALENs, transposons, and related applications; utilize lentiviral vectors to genetically modify freshly isolated T-lymphocytes.
· Use cutting-edge science and emerging developments to identify opportunities to deliver innovative best-in-class therapies.
· Identify original, nascent solutions to key scientific challenges required for success.
· Support the development of therapies focused on engineered T cells.
· Deliver reports, summaries, and presentations supporting experimental results.

Desired profile

Qualifications :

·  Ph.D. with at least 3 years of lab-based experience in the CAR T-cell field is required
·  Post-doctoral experience in a CAR-T lab is preferred
·  Experience with cell engineering is required and T cell engineering is preferred
·  Must be wholly proficient with flow cytometry-based applications is required
·  Experience in independently proposing, designing, executing, and reporting research projects is required
·  Strong record of publications is preferred
·  Possess the ability to solve complex problems in a creative scientific fashion
·  Outstanding collaborative and communication skills
·  Foster a working environment that encourages the company's commitment to equal employment opportunity and the value of a diverse work force