Master student
- Chimie / Biologie / Agronomie Study of the effects of mutations on a protein-protein interaction involved in cancers (YAP-TEAD involved in Hippo pathway).
In order to study thermodynamical parameters (enthalpy/ΔH, entropy/ΔS, heat capacity/ΔCp) and affinity constant (Kd), I had to use several biophysical techniques such as :
-DSF (thermofluor)
-ITC (microcalorimetry)
-TR-FRET (fluorescence)
- SPR
-CD