Expire bientôt Univ. Grenoble Alpes

FUNDED PhD and M2 INTERNSHIP PROPOSAL : EVANESCENT FIELD PATTERNING FOR OPTOGENETIC ACTIVATION OF LIVE CELLS

  • CDD
  • Entre 25 mois et 36 mois
  • Grenoble (Isère)
  • Master, Titre d'ingénieur, Bac +5
  • Chimie / Biologie / Agronomie

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Description de l'offre

We propose to develop a optical setup for programmable patterned evanescent field illumination, in order to directly activate the basal membrane of a cell adhering on a substrate, rather than the standard cytosolic (i.e. bulk) activation. To control the incident light field, a wavefront shaping approach will be performed using a Digital Micromirror Device (DMD).
The project entails both simulations, to optimize the pattern to apply on the DMD for a desired illumination pattern, and developing an optical bench to test this approach and define the best optical configuration compatible with a microscope environment.
This internship and PhD will take place in Grenoble, at the Laboratory for Interdisciplinary Physics (LIPhy) and at the Institute for Advanced Biosciences (IAB).

Profil recherché

This internship requires a background in optics/physics. We are especially interested by applicants who would be willing to continue this internship with a PhD, which has been recently funded by the ANR.

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