Description de l'offre
We propose to develop a optical setup for programmable patterned evanescent field illumination, in order to directly activate the basal membrane of a cell adhering on a substrate, rather than the standard cytosolic (i.e. bulk) activation. To control the incident light field, a wavefront shaping approach will be performed using a Digital Micromirror Device (DMD).
The project entails both simulations, to optimize the pattern to apply on the DMD for a desired illumination pattern, and developing an optical bench to test this approach and define the best optical configuration compatible with a microscope environment.
This internship and PhD will take place in Grenoble, at the Laboratory for Interdisciplinary Physics (LIPhy) and at the Institute for Advanced Biosciences (IAB).
This internship requires a background in optics/physics. We are especially interested by applicants who would be willing to continue this internship with a PhD, which has been recently funded by the ANR.